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Download Syllabus --- here
Primary contact: D. Eric Aston, Department of Chemical Engineering, Buchanan Engineering Lab. (BEL), Rm 301, 885-6953, aston@uidaho.edu
Class Meeting Time: Tuesdays & Thursdays 2:00-3:15 p.m. LIFE 163
Welcome! The goal of this course is to provide students with the basic tools in chemistry, physics, engineering and biology necessary to appreciate the technological applications of nanomaterials in biologically relevant studies. Students will also be acquainted with physical methods and tools used to characterize the fundamental properties of nanomaterials and measure their behavior in a variety of environments.
Lectures will be given by a variety of faculty, staff, and students from different departments and colleges in the university (see schedule below). Some specialized lectures will be given highlighting the presenter's expertise in a particular field.
No textbook is assigned. Most readings will be from relevant journals. You must download reading material from the BANTech course website or via direct instructor e-mails. We expect you to read this material before each section as the basis for discussions during lecture.
Class by Week
Week 1: Jan 15 (Aston/Beaux) Introduction: Appreciating the Nanoscale for Biological Applications
Why nanobio? Surface science and the impact on nanomaterials
Basic structure and expectations of class lectures and discussions; final project formats; etc.
READING ASSIGNMENTS --- here & here
Week 2: Jan 20, 22 (McIlroy) Surface Instrumentation for BioNano Apps Part I
Reading Assignment(s): Beaux, McIlroy, Gustin, Expert Opin. Drug Deliv. 2008 5(7): 725-35.
READING ASSIGNMENTS --- here & here
Additional READING ASSIGNMENTS --- here & here
Week 3: Jan 27, 29 (Choi) Theory behind Nanomaterials and their Applications
Reading Assignments: The essay from Scientific American (September 2001), "The Art of Building Small" by George M. Whitesides and J. Christopher Love
READING ASSIGNMENT --- here
Week 4: Feb 3, 5 (Aston) Nanomaterial Interactions: Colloids, Macromolecules, and Surface Chemistry
Reading Assignment(s): Dedecker, Hofkens, Hotta. "Diffraction-unlimited Optical Microscopy." Materials Today Microscopy Special Issue (2008) 12-21.
http://www.nxtbook.com/nxtbooks/elsevier/materialstoday/
READING ASSIGNMENT --- tba
Week 5: Feb 10, 12 (Aston) Surface Instrumentation Part II: AFM, NSOM, Raman, etc.
Reading Assignments: TBA + Smit et al. Rev. Sci. Instrum. 78 (2007) 113705; Cockins et al. Rev. Sci. Instrum. 78 (2007) 113706; Valbuena et al. Rev. Sci. Instrum. 78 (2007) 113707.
READING ASSIGNMENTS --- here & here & here
Week 6: Feb 17, 19 (Ytreberg) Role of Computer Simulation in Bionanoscience
Reading Assignments: Molecular Dynamics Simulations Tutorial: R Stote, et al.
Lu et al. Phys. Biol., 3:S40-S53 (2006).
READING ASSIGNMENTS ---here & here
Week 7: Feb 24, 26 (Papasani/Hill) "NanoBioscience" in Molecular Biology
Reading Assignments: V. Labhasetwar, Current Op. Biotechnol. 2005, 16(6): 674-80.
General Cell Biology Background: Molecular Biology of the Cell
, 4th Ed. (or equivalent), particularly parts of chapters 6 (DNA to RNA and RNA to protein), 7 (gene control), 10 (lipid bilayer) & 12 (cell compartmentalization). Cell surface/subcellular markers/endosomal pathways.
VIEW AND REVIEW --- This & This
Week 8: Mar 3, 5 (Papasani/Hill) Cellular Organization and Gene Expression
Reading Assignments: Tkachenko et al. Bioconjug. Chem. 2007, 15(13) 482-90.
Kelly et al. Org. Biomol. Chem. 2008, 6, 2242-55.
VIEW AND REVIEW --- This
READING ASSIGNMENTS --- here & here
Week 9: Mar 10, 12 (Hrdlicka) Nanomaterial-mediated Cellular Uptake of Therapeutic and Diagnostic Nucleic Acid Probes
Reading Assignments: Eur. J. Biochem. 2003, 270, 1628-44; Nature Chem. Biol. 2006, 711-19.
Nucleic Acids Research 2008, 4158-71.
Angewandte Chemie International Edition 2008, 1382-95.
READING ASSIGNMENTS --- here & here & here & here
Week 10: Mar 24, 26 (Hrdlicka) Increasing Bioavailability and Bioactivity of Nanomaterials
Reading Assignments: Science 2006, 312, 1027-30 + supporting information (SI).
Chem. Bio. Chem. 2007, 8, 1230-1232 + SI.
Nano Letters 2007, 3818-21; J. Am. Chem. Soc. 2007, 15477-79 + SI.
READING ASSIGNMENTS --- here & here & here & here & here & here & here
Week 11: Mar 31, Apr 2 (Corti, Branen) Bionanosensor Fabrication and Detection
Reading Assignments: Wang, J., Nanomaterial-based electrochemical biosensors. Analyst, 2005. 130(4): pp. 421-26; Cheng, M.M.-C., et al., Nanotechnologies for biomolecular detection and medical diagnostics. Current Opinion in Chemical Biology, 2006. 10(1): pp. 11-19. Peterson, K., Sillicon as a mechanical material. IBM, Source: Proceedings of the IEEE, 1982, v 70, n 5, pp. 420-457, ISSN: 0018-9219 CODEN: IEEPAD.
READING ASSIGNMENTS --- here & here & here
Week 12: Apr 7, 9 (Nagler) Applications of Nanomaterials in Biology: Design of a Targeted Approach for In Vivo Delivery of a Nanomaterial
Reading Assignments: Biomed. Microdevices doi 10.1007/s10544-008-9209-0.
READING ASSIGNMENT --- here
Week 13: Apr 14, 16 (Stenkamp) Medical Applications and Toxicology
READING ASSIGNMENTS --- here & here
Weeks 14-16: Apr 21, 23, 28, 30 and May 5, 7 (All Faculty) Student presentations (two presentations per lecture)
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